Hi, I would like to request the names of the 20 ‘hidden’ genes. I assume they are not just a random subset, but have been carefully selected. Therefore, understanding their role, the pathways they are involved in, the disease context, and their general significance is crucial when mapping them to the reference single-cell data. Without this context, prioritizing the signal could seem arbitrary, as it would be like searching for something without knowing what to look for. Since we have both validation and test sets, knowing which genes are included should be feasible.
For example, if these 20 genes are general cell-supporting genes, a reference cell type atlas that broadly captures a variety of cell types and functions would be most appropriate. However, if the genes are disease-specific, then a reference atlas focused on the particular disease context would be much more relevant. This distinction would ensure that the gene mapping is contextually accurate and meaningful.
Participant must provide a generalized solution that works for all genes. Not just focus on the 20 selected.